It literally means many or plenty, from the English word enough.
(a). It means a lot or many or plenty.
(b). Used to describe a nosy person; one who likes to poke their nose into people's businesses and doesn't mind theirs.
(patois) Nuff a dem nuh know wah a gwaan
(english) Many of them don't know what's going on(what's happening).
(patois) Yow! Yuh too nuff, a wah happen to yuh? Go sidung, man. Go weh!
(english) Hey! You are too nosy, what's the problem with you? Go take a seat, dude. Go away!
many / alot of
Patois: Mi need nuff gals fi di party
English: I need alot of girls for the party
Patois: Nuff gyal deh a mi party
English: Plenty of girls are at my party
Means any of the following: plenty, too much, many, tons, a lot, etc...
(patois) Yow Chef! mi waah nuff food
(english) Hey Chef! I want a lot of food